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These tasks are shared among different cell types: If we manage to freeze the mobility of PqsBC with an agent, we would be able to specifically inhibit PqsBC and disrupt the communication of P. Dustin to simulate the formation of synapses using computer models. Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly. A quantitative analysis of the converted fatty acids showed that chains made up of eight carbon atoms are incorporated most frequently.

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    One key to the success of this persistent pathogen is its complex communication system as the bacteria use various signalling substances to communicate with each other and to control infection processes. PqsBC exists in different conformational states. Anastasios Siokis, Philippe A.

    Robert, Philippos Demetriou, Michael L. Today, the researchers have published their results in the scientific journal Cell Reports. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information.

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    Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed. Cell Reports,DOI: At the end of this process the T-cell is either activated or remains inactive.

    They even manage to survive most antibiotics by shielding themselves in a dense biofilm or by simply pumping the toxins from their interior with the help of small pumps.

    The three-dimensional structure of the protein complex also demonstrates that the length of the channel is such that it is filled up by a fatty acid chain consisting of eight carbon atoms. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information.

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    Press Release – Helmholtz Zentrum München

    To ensure top quality research we need top quality employees. with this carbon chain is the one that is best recognised by the receptor of the.
    In order to take a look behind the curtains of this versatile protein complex, Florian Witzgall, who is a doctoral student in Blankenfeldt's department, carefully purified the protein complex and then crystallised it and determined the three-dimensional structure of PqsBC using x-ray diffraction analysis.

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    HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Dustin to simulate the formation of synapses using computer models. The immune system protects the human body against pathogens thus keeping it healthy. They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse.

    The antigen receptors are small and are repelled by the large adhesion molecules. The large diversity of the signalling substances presumably relates to the fact that both shorter and longer fatty acids fit into the channel and can be processed, albeit less efficiently.

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    Computer simulations can be used to derive a dynamic mechanism from these states, in which PqsBC can bind to the fatty acid chain by closing the molecule.

    This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.

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    Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information.

    The antigen receptors are small and are repelled by the large adhesion molecules. The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface.

    The detail enlargement shows that the channel has an optimal length for binding a fatty acid chain of eight carbon atoms. Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area.

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    Involved Groups Systems Immunology.

    The antigen receptors are small and are repelled by the large adhesion molecules. Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. The detail enlargement shows that the channel has an optimal length for binding a fatty acid chain of eight carbon atoms.

    Today, the researchers have published their results in the scientific journal Cell Reports.

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    The ability of a single protein complex to change its shape allows the bacteria to process molecules of different sizes into signalling substances. A quantitative analysis of the converted fatty acids showed that chains made up of eight carbon atoms are incorporated most frequently.

    HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. One very promising target is one of the communication systems — the so-called pqs system Pseudomonas quinolone signalwhich is present as such only in P. The detail enlargement shows that the channel has an optimal length for binding a fatty acid chain of eight carbon atoms.

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    1. The ability of a single protein complex to change its shape allows the bacteria to process molecules of different sizes into signalling substances. To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface.

    2. Today, the researchers have published their results in the scientific journal Cell Reports. It produces molecules that have similar structures, but differ in the length of their fatty acids chains, although the exact molecular details of this were previously unknown.

    3. HZI researchers investigated the formation of signalling substances in Pseudomonas and discovered a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals.

    4. In order to take a look behind the curtains of this versatile protein complex, Florian Witzgall, who is a doctoral student in Blankenfeldt's department, carefully purified the protein complex and then crystallised it and determined the three-dimensional structure of PqsBC using x-ray diffraction analysis.

    5. Computer simulation of an immunological synapse with its characteristic ring-shaped structure. This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.